Xbox 360 Top LIVE Titles (based on UU’s)
1    Halo 3
2    Call of Duty 4
3    Call of Duty: WaW
4    GTA IV 
5    Halo 3: ODST
6    Gears of War 2
7    FIFA 10
8    Borderlands
9    Madden NFL 10 
10  Forza Motorsport 3

Top Arcade Titles (Full Versions purchased)
1    Trials HD   
2    SOUTH PARK LET'S GO TOWER DEFENSE PLAY!
3    Zombie Apocalypse
4    Battlefield 1943
5    Tower Bloxx Deluxe
6    Castle Crashers 
7    Magic: The Gathering
8    Fable II Pub Games
9    Panzer General Allied Assault
10  Shadow Complex 

Original Xbox Top Live Titles (based on UU’s)
1    Halo 2
2    Star Wars: Battlefront 2
3    Counter-Strike
4    Fable
5    Conker: Live Reloaded
6    Splinter Cell Chaos
7    Doom 3
8    Star Wars: Battlefront
9    SW: Republic Commando
10  Call of Duty 3

Top Indie Games (Full Versions purchased)
1   Avatar Drop 
2   I MAED A GAM3 W1TH Z0MB1ES!!!1
3   Pumpkin Chop 
4   Miner Dig Deep
5   Headshot  
6   Run Away
7   Avatar Golf 
8   Halloween HD
9   Beat Hazard
10 Night Of Doom

The data is based on global unique users who are connected to Xbox Live. With Xbox Live Arcade or Indie Games, the data is taken from full copies purchased/downloaded.

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Source - Major Nelson